COVID-19 studies:  C19 studies: C19:  IvermectinIVM Vitamin DV.D HC QHC Q Vitamin CV.C ZincZn PVP-IPVP-I REGNREGN LY-CoVLY RemdesivirRMD
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00.250.50.7511.251.51.752+Zhang (RCT)0.50[0.20-1.80]56RRCINKumari (RCT)0.64[0.26-1.55]150JamaliMoghad.. (RCT)1.00[0.22-4.56]60Tau​2 = 0.00; I​2 = 0.0%Late0.61[0.34-1.07]266 (n)39% improvementBehera0.90[0.67-1.21]372Tau​2 = 0.00; I​2 = 0.0%PrEP0.90[0.67-1.21]372 (n)10% improvementAll studies0.83[0.64-1.08]638 (n)17% improvementAll vitamin C COVID-19 studiesTau​2 = 0.00; I​2 = 0.0%; Z = 1.39 (p = 0.083)Lower RiskIncreased Risk
1/9
Late JamaliMoghadamSiahkali et al., Research Square, doi:10.21203/rs.3.rs-139942/v1 (Preprint) death, 0.0%, p=1.00 Safety and Effectiveness of High-Dose Vitamin C in Patients with COVID-19; A Randomized Controlled open-label Clinical Trial
Small RCT for the addition of vitamin C to HCQ and lopinavir/ritonavir, not finding significant improvements. Dose was 6g/day.
11/30
Late Kumari et al., Cureus 12(11): e11779, doi:10.7759/cureus.11779 (Peer Reviewed) death, ↓36.4%, p=0.45 The Role of Vitamin C as Adjuvant Therapy in COVID-19
RCT 150 hospitalized patients in Pakistan showing 26% faster recovery, p < 0.0001. 36% lower mortality, not statistically significant due to the small number of events. Dosage was 50 mg/kg/day of intravenous vitamin C.
11/3
PrEP Behera et al., medRxiv, doi:10.1101/2020.10.29.20222661v1 (Preprint) cases, ↓9.6%, p=0.58 Role of ivermectin in the prevention of COVID-19 infection among healthcare workers in India: A matched case-control study
Retrospective prophylaxis study for HCQ, ivermectin, and vitamin C with 372 healthcare workers, showing lower COVID-19 incidence for all treatments, with statistical significance reached for ivermectin. HCQ OR 0.56, p = 0.29 Ivermectin O..
8/10
Late Zhang et al., Research Square, doi:10.21203/rs.3.rs-52778/v2 (Preprint) death, ↓50.0%, p=0.31 Pilot Trial of High-dose vitamin C in critically ill COVID-19 patients
Small RCT for high dose vitamin C for ICU patients showing reduced (but not statistically significant) mortality. Dosage was 12g of vitamin C/50ml every 12 hours for 7 days at a rate of 12ml/hour.
7/25
Review Feyaerts et al., Nutrition, doi:10.1016/j.nut.2020.110948 (Review) (Peer Reviewed) review Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19?
Review concluding that there is clear evidence that vitamin C in high doses can reduce interleukin-6 and endothelin-1 mediators. Authors suggest a relatively low dose as prophylaxis, and in cases of severe COVID-19, an (intravenous) high-..
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