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Vitamin C study #17 of 23   All Outcomes
4/2 Late treatment study
Al Sulaiman et al., Research Square, doi:10.21203/rs.3.rs-354711/v1 (Preprint)
Ascorbic Acid as an Adjunctive Therapy in Critically Ill Patients with COVID-19: A Multicenter Propensity Score Matched Study
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Retrospective 158 critically ill patients receiving vitamin C and propensity matched controls, showing mortality OR 0.77 [0.48-1.23], and statistically significantly lower thrombosis, OR 0.42 [0.18-0.94]. 1000mg of vitamin C was given daily.

Al Sulaiman et al., 4/2/2021, retrospective, Saudi Arabia, Middle East, preprint, 12 authors.
risk of death, 14.9% lower, RR 0.85, p = 0.27, treatment 46 of 142 (32.4%), control 59 of 142 (41.5%), odds ratio converted to relative risk, PSM.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 23 studies   All Outcomes
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