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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Recovery 4% Improvement Relative Risk c19vitaminc.com Fogleman et al. NCT04530539 Vitamin C RCT LATE TREATMENT Favors vitamin C Favors control
Fogleman, 66 patient vitamin C late treatment RCT: 4% improved recovery [p=0.83] https://c19p.org/foglemanc
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A Pilot of a Randomized Control Trial of Melatonin and Vitamin C for Mild-to-Moderate COVID-19
Fogleman et al., The Journal of the American Board of Family Medicine, doi:10.3122/jabfm.2022.04.210529, NCT04530539 (history)
27 Jul 2022    Source   PDF   Share   Tweet
Early terminated low-risk patient RCT with 32 low-dose vitamin C, 32 melatonin, and 34 placebo patients, showing faster resolution of symptoms with melatonin in spline regression analysis, and no significant difference for vitamin C. All patients recovered with no serious outcomes reported. Baseline symptoms scores were higher in the melatonin and vitamin C arms (median 27 and 24 vs. 18 for placebo).
relative recovery, 4.4% better, RR 0.96, p = 0.83, treatment mean 17.59 (±13.1) n=32, control mean 16.82 (±15.7) n=34, mid-recovery, relative symptom improvement, day 9.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Fogleman et al., 7/27/2022, Double Blind Randomized Controlled Trial, placebo-controlled, USA, peer-reviewed, mean age 52.0, 7 authors, study period 5 October, 2020 - 21 June, 2021, average treatment delay 6.0 days, trial NCT04530539 (history).
Contact: corey.fogleman@pennmedicine.upenn.edu.
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