The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study

2/26 Late treatment study

Gao et al., Aging, doi:10.18632/aging.202557 (Peer Reviewed)
The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study

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Retrospective 76 COVID-19 patients, 46 treated with intravenous high-dose vitamin C, showing lower mortality and improved oxygen requirements with treatment. Dosage was 6g intravenous infusion per 12hr on the first day, and 6g once for the following 4 days.

Gao et al., 2/26/2021, retrospective, China, Asia, peer-reviewed, 14 authors.

risk of death, 86.0% lower, RR 0.14, p = 0.04, treatment 1 of 46 (2.2%), control 5 of 30 (16.7%), adjusted per study, KM.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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