Hess, 100 patient vitamin C late treatment study: 20% lower mortality [p=0.54], 40% lower ventilation [p=0.05], and 27% lower ICU admission [p=0.11] https://c19p.org/hess
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High-dose intravenous vitamin C decreases rates of mechanical ventilation and cardiac arrest in severe COVID-19
et al., Internal and Emergency Medicine, doi:10.1007/s11739-022-02954-6
Retrospective 100 severe condition hospitalized patients in the USA, 25 treated with high dose IV vitamin C, showing lower mechanical ventilation and cardiac arrest, and increased length of survival with treatment. 3g IV vitamin C every 6h for 7 days.
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risk of death, 20.0% lower, HR 0.80, p = 0.54, treatment 10 of 25 (40.0%), control 37 of 75 (49.3%), NNT 11, time to event analysis, inverse propensity weighting.
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risk of mechanical ventilation, 39.5% lower, RR 0.60, p = 0.0499, treatment 18 of 25 (72.0%), control 54 of 75 (72.0%), odds ratio converted to relative risk, inverse propensity weighting.
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risk of mechanical ventilation, 50.0% lower, HR 0.50, p = 0.03, treatment 18 of 25 (72.0%), control 54 of 75 (72.0%), time to event analysis, inverse propensity weighting.
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risk of ICU admission, 27.2% lower, RR 0.73, p = 0.10, treatment 22 of 25 (88.0%), control 63 of 75 (84.0%), odds ratio converted to relative risk, inverse propensity weighting.
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risk of ICU admission, 30.0% lower, HR 0.70, p = 0.19, treatment 22 of 25 (88.0%), control 63 of 75 (84.0%), time to event analysis, inverse propensity weighting.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Hess et al., 3/29/2022, retrospective, USA, North America, peer-reviewed, 9 authors, study period March 2020 - July 2020.
Late treatment
is less effective
is less effective
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