Retrospective 152 mechanically ventilated patients in the USA showing unadjusted lower mortality with vitamin C, vitamin D, HCQ, and zinc treatment, statistically significant only for vitamin C.
Krishnan et al., 7/20/2020, retrospective, USA, North America, peer-reviewed, 13 authors.
risk of death, 30.7% lower, RR 0.69, p < 0.001, treatment 40 of 79 (50.6%), control 52 of 73 (71.2%), adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.