Use of Intravenous Vitamin C in Critically Ill Patients With COVID-19 Infection

6/8 Late treatment study

Li et al., Journal of Pharmacy Practice, doi:10.1177/08971900211015052 (Peer Reviewed)
Use of Intravenous Vitamin C in Critically Ill Patients With COVID-19 Infection

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PSM retrospective 8 ICU patients treated with vitamin C and 24 matched controls, showing no significant difference. Authors note that "it is possible for the delayed timing of IV vitamin C to have blunted the beneficial effects as these patients may have already progressed to the late fibroproliferative phase or ARDS". IV vitamin C 1.5 grams every 6 hours.

Li et al., 6/8/2021, retrospective, propensity score matching, USA, North America, peer-reviewed, 6 authors.

risk of death, 10.5% higher, RR 1.11, p = 1.00, treatment 7 of 8 (87.5%), control 19 of 24 (79.2%), PSM.

This study is excluded in meta analysis: very late stage, ICU patients.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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