The use of vitamin C in the intensive care unit during the COVID-19 pandemic

7/4 Late treatment study

Özgünay et al., The European Research Journal, doi:10.18621/eurj.938778 (Peer Reviewed)
The use of vitamin C in the intensive care unit during the COVID-19 pandemic

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Retrospective 160 ICU patients, 32 with raised neutrophil/lymphocyte ratio treated with vitamin C, showing no significant differences.

Özgünay et al., 7/4/2021, retrospective, Turkey, Europe, peer-reviewed, 7 authors.

risk of death, 9.3% lower, RR 0.91, p = 0.69, treatment 17 of 32 (53.1%), control 75 of 128 (58.6%).

risk of mechanical ventilation, 1.1% higher, RR 1.01, p = 1.00, treatment 23 of 32 (71.9%), control 91 of 128 (71.1%).

This study is excluded in meta analysis: substantial unadjusted confounding by indication likely.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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