The significance of oral ascorbic acid in patients with COVID-19

10/1 Late treatment study

Patel et al., Chest Infections, doi:10.1016/j.chest.2020.08.322 (Peer Reviewed)
The significance of oral ascorbic acid in patients with COVID-19

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Retrospective 176 hospitalized patients, 96 treated with oral vitamin C (from 500mg to 1500mg daily), showing lower mortality with treatment.

Patel et al., 10/1/2020, retrospective, USA, North America, peer-reviewed, 8 authors.

risk of death, 29.5% lower, RR 0.71, p = 0.18, treatment 22 of 96 (22.9%), control 26 of 80 (32.5%).

risk of death, 15.6% lower, RR 0.84, p = 0.60, treatment 15 of 30 (50.0%), control 16 of 27 (59.3%), ICU patients.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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