Rosenthal: Risk Factors Associated With In-Hospital Mortality in a US National Sample of Patients With COVID-19

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Rosenthal, vitamin C late treatment study: 11% lower mortality [p=0.005] https://c19p.org/rosenthalc

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Risk Factors Associated With In-Hospital Mortality in a US National Sample of Patients With COVID-19

Rosenthal et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2020.29058

10 Dec 2020 Source PDF Share Tweet

Retrospective database analysis of 64,781 hospitalized patients in the USA, showing lower mortality with vitamin C or vitamin D (authors do not distinguish between the two), and higher mortality with zinc and HCQ, statistically significant for zinc. Authors excluded hospital-based outpatient visits, without explanation. Confounding by indication is likely, adjustments do not appear to include any information on COVID-19 severity at baseline.

risk of death, 11.0% lower, OR 0.89, p = 0.005, adjusted per study, vitamin C or vitamin D, multivariable, RR approximated with OR.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

This study is excluded in meta analysis: results are only provided for use of one or more treatments within a class of treatments, results for each treatment are not provided, confounding by indication is likely and adjustments do not consider COVID-19 severity at baseline.

Rosenthal et al., 12/10/2020, retrospective, database analysis, USA, North America, peer-reviewed, 5 authors.

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Late treatment
is less effective

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