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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 21% Improvement Relative Risk ICU admission -2% Vitamin C for COVID-19  Suna et al.  LATE TREATMENT Is late treatment with vitamin C beneficial for COVID-19? Retrospective 323 patients in Turkey Lower mortality with vitamin C (not stat. sig., p=0.52) c19early.org Suna et al., Med. Clin., May 2021 Favors vitamin C Favors control

Effect of high-dose intravenous vitamin C on prognosis in patients with SARS-CoV-2 pneumonia

Suna et al., Med. Clin. (Barc.), doi:10.1016/j.medcli.2021.04.010
May 2021  
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Vitamin C for COVID-19
7th treatment shown to reduce risk in September 2020
 
*, now known with p = 0.00000011 from 68 studies, recognized in 10 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
Retrospective 323 hospitalized patients, 153 treated with vitamin C, showing no significant differences. Patients in each group were in different time periods, with the vitamin C group first. Time based confounding is possible due to improvements in SOC.
Although the 21% lower mortality is not statistically significant, it is consistent with the significant 19% lower mortality [9‑28%] from meta analysis of the 40 mortality results to date.
This is the 25th of 68 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.00000011.
19 studies are RCTs, which show efficacy with p=0.0021.
This study is excluded in the after exclusion results of meta analysis: substantial confounding by time likely due to declining usage over the early stages of the pandemic when overall treatment protocols improved dramatically.
risk of death, 21.3% lower, RR 0.79, p = 0.52, treatment 17 of 153 (11.1%), control 24 of 170 (14.1%), NNT 33.
risk of ICU admission, 1.9% higher, RR 1.02, p = 1.00, treatment 11 of 153 (7.2%), control 12 of 170 (7.1%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Suna et al., 11 May 2021, retrospective, Turkey, peer-reviewed, 5 authors.
This PaperVitamin CAll
Effect of high-dose intravenous vitamin C on prognosis in patients with SARS-CoV-2 pneumonia
Uzel S ¸ ener Kavurgacı Suna, Uzel Şener Melahat, Yıldız Murat, Öztürk Ergür Figen, Öztürk Ayperi
Medicina Clínica, doi:10.1016/j.medcli.2021.04.010
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Conflict of interest The authors declare that they have no conflict of interest.
References
Alhazzani, Møller, Arabi, Loeb, Gong, Surviving sepsis campaign: guidelines on the management of critically ill adults with coronavirus disease 2019 (COVID-19), Intensive Care Med, doi:10.1007/s00134-020-06022-5
Aziz, Fatima, Assaly, Elevated interleukin-6 and severe COVID-19: a metaanalysis, J Med Virol, doi:10.1186/1743-7075-3-35
Barness, Safety considerations with high ascorbic acid dosage, Ann N Y Acad Sci, doi:10.1080/1478721020201794819
Campbell, Steinberg, Bower, Letter: ascorbic acidinduced hemolysis in G-6-PD deficiency, Ann Intern Med, doi:10.1111/j.1749-6632.1975.tb29311.xb
Cheng, Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)?, Med Drug Discov, doi:10.1016/j.medidd.2020.100028
Fijen, Weijmer, Acute oxalate nephropathy due to high vitamin C doses and exocrine pancreatic insufficiency, BMJ Case Rep, doi:10.7326/0003-4819-82-6-810_1
Fowler, Truwit, Hite, Morris, Dewilde, Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial, JAMA, doi:10.1016/j.chest.2016.11.036
Fujii, Luethi, Young, Frei, Eastwood et al., Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: the vitamins randomized clinical trial, JAMA, doi:10.1093/jn/137.7.1757
Hiedra, Lo, Elbashabsheh, Gul, Wright et al., The use of IV vitamin C for patients with COVID-19: a case series, Expert Rev Anti Infect Ther, doi:10.21037/apm-20-1387
Hiedra, Lo, Elbashabsheh, Gul, Wright et al., The use of IV vitamin C for patients with COVID-19: a case series, Expert Rev Anti Infect Ther, doi:10.1001/jama.2019.22176
Jayawardena, Sooriyaarachchi, Chourdakis, Jeewandara, Ranasinghe, Enhancing immunity in viral infections, with special emphasis on COVID-19: a review, Diabetes Metab Syndr, doi:10.1007/s00134-020-06022-5
Johnston, Beezhold, Mostow, Swan, Plasma vitamin C is inversely related to body mass index and waist circumference but not to plasma adiponectin in nonsmoking adults, J Nutr, doi:10.1016/j.medidd.2020.100028
Johnston, Corte, Swan, Marginal vitamin C status is associated with reduced fat oxidation during submaximal exercise in young adults, Nutr Metab, doi:10.1186/s13054-018-2191-x
Li, Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis, Crit Care, doi:10.1186/s13054-018-2191-x
Marik, Khangoora, Rivera, Hooper, Catravas, Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study, Chest, doi:10.7326/0003-4819-140-7-200404060-00010
Medcli-, None
Mehta, Mcauley, Brown, Sanchez, Tattersall et al., COVID-19: consider cytokine storm syndromes and immunosuppression, Lancet, doi:10.1016/S0140-6736(20)30628-0
Padayatty, Sun, Wang, Riordan, Hewitt et al., Vitamin C pharmacokinetics: implications for oral and intravenous use, Ann Intern Med, doi:10.1080/14787210.2020.1794819
Suna, Melahat, Murat, None, Medicina Clínica xxx
Wang, Hu, Hu, Zhu, Liu et al., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus infected pneumonia in Wuhan, China, JAMA, doi:10.1002/jmv.25948
Zhao, Ling, Li, Peng, Huang et al., Beneficial aspects of high dose intravenous vitamin C on patients with COVID-19 pneumonia in severe condition: a retrospective case series study, Ann Palliat Med, doi:10.1001/jama.2020.1585
Late treatment
is less effective
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