et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2021.0369 (Peer Reviewed)
Small 214 low-risk outpatient RCT showing non-statistically significant faster recovery with zinc and with vitamin C. NCT04342728.
A secondary analysis concludes that vitamin C increases recovery rate by 71% (p
= 0.036) . See also .
Thomas et al., 2/12/2021, Randomized Controlled Trial, USA, North America, peer-reviewed, 11 authors.
recovery time, 17.9% lower, relative time 0.82, p = 0.38, treatment 48, control 50, mean time to a 50% reduction in symptoms, p value approximated with combined p value in study.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.