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Home   COVID-19 treatment studies for Vitamin C  COVID-19 treatment studies for Vitamin C  C19 studies: Vitamin C  Vitamin C   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Mortality -157% Improvement Relative Risk Mortality (b) -169% Clinical improvement ≥.. -35% Clinical improvement ≥.. (b) -32% c19vitaminc.com/zheng.html Favors vitamin C Favors control
22 September 2021 - Late treatment study
No significant benefit of moderate-dose vitamin C on severe COVID-19 cases
Zheng et al., Open Medicine, doi:10.1515/med-2021-0361 (Peer Reviewed)
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Retrospective 397 severe COVID-19 patients in China, showing worse outcomes with vitamin C treatment, without statistical significance. IV vitamin C 2-4g/day. Subject to confounding by indication and immortal time bias. Exclusion criteria were (a) the duration of hospitalization was less than 3 days; (b) vitamin C treatment started before admission; and (c) the length of vitamin C use was less than 3 days. Includes vitamin C use started at any time during hospitalization, for many patients this was >15 days later (Figure A2). Duration of treatment varied widely (Figure A1). Treatment was determined by clinicians according to the condition of each patient.
risk of death, 157.0% higher, RR 2.57, p = 0.33, treatment 12 of 70 (17.1%), control 7 of 327 (2.1%), adjusted per study, propensity score matching.
risk of death, 169.0% higher, RR 2.69, p = 0.07, treatment 12 of 70 (17.1%), control 7 of 327 (2.1%), adjusted per study, IPTW.
clinical improvement ≥ 2 points, 35.1% worse, RR 1.35, p = 0.17, treatment 18 of 70 (25.7%), control 16 of 327 (4.9%), adjusted per study, propensity score matching.
clinical improvement ≥ 2 points, 31.6% worse, RR 1.32, p = 0.11, treatment 18 of 70 (25.7%), control 16 of 327 (4.9%), adjusted per study, IPTW.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely, immortal time bias may significantly affect results, treatment start times unknown, treatment may not have started at baseline.
Zheng et al., 9/22/2021, retrospective, China, Asia, peer-reviewed, 10 authors, study period 13 February, 2020 - 29 February, 2020.
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