Hellou, 50 patient vitamin C late treatment RCT: 77% improved recovery [p=0.04], 92% lower need for oxygen therapy [p=0.01], 13% shorter hospitalization [p=0.92], and 10% improved viral clearance [p=0.77] https://c19p.org/hellouc
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Effect of ArtemiC in patients with COVID-19: A Phase II prospective study
et al., Journal of Cellular and Molecular Medicine, doi:10.1111/jcmm.17337
RCT 50 hospitalized patients in Israel, 33 treated with curcumin, vitamin C, artemisinin, and frankincense oral spray, showing improved recovery with treatment.
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relative NEWS2 score, 76.7% better, RR 0.23, p = 0.04, treatment mean 0.52 (±0.67) n=33, control mean 2.23 (±3.2) n=17, day 15.
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risk of oxygen therapy, 92.2% lower, RR 0.08, p = 0.01, treatment 0 of 33 (0.0%), control 4 of 17 (23.5%), NNT 4.2, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 15.
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oxygen time, 69.7% lower, relative time 0.30, p = 0.17, treatment mean 2.3 (±1.4) n=33, control mean 7.6 (±4.6) n=17.
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hospitalization time, 13.3% lower, relative time 0.87, p = 0.92, treatment mean 7.8 (±7.3) n=33, control mean 9.0 (±8.0) n=17.
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risk of no viral clearance, 9.8% lower, RR 0.90, p = 0.77, treatment 14 of 33 (42.4%), control 8 of 17 (47.1%), NNT 22, day 15.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
This study is excluded in meta
analysis:
combined treatments may contribute more to the effect seen.
Hellou et al., 5/19/2022, Double Blind Randomized Controlled Trial, placebo-controlled, Israel, Middle East, peer-reviewed, 6 authors, this trial uses multiple treatments in the treatment arm (combined with curcumin, artemisinin, and frankincense) - results of individual treatments may vary, trial NCT04382040.
Late treatment
is less effective
is less effective
hellou
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