NBS superfood: a promising adjunctive therapy in critically ill ICU patients with omicron variant of COVID-19

{ 'DOI': '10.1186/s13568-024-01690-8', 'ISSN': ['2191-0855'], 'URL': 'http://dx.doi.org/10.1186/s13568-024-01690-8', 'abstract': '<jats:title>Abstract</jats:title><jats:p>This clinical trial aimed to assess the impact of ' 'Nutrition Bio-shield superfood (NBS) on clinical status among critically ill ICU patients ' 'suffering from acute respiratory distress syndrome (ARDS) due to the Omicron variant of ' 'COVID-19. A total of 400 patients with confirmed Omicron-related ARDS were randomly assigned ' 'to either the intervention group (n\u2009=\u2009200) or the control group (n\u2009=\u2009' '200). Patients in the intervention group received 1.5\xa0g of NBS powder daily for 2\xa0weeks ' 'in addition to standard antiviral treatment, while the control group received a placebo ' 'alongside standard antiviral therapy. Serum samples were collected from all patients in both ' 'groups, and various clinical and laboratory parameters, including ESR, CRP, D-Dimer, CPK, WBC ' 'count, lymphocyte count, and lymphocyte percentage, were measured using established ' 'methodologies. Following a 14-day intervention period, the intervention group exhibited a ' 'significant reduction in mean serum levels of CRP (15.39 vs. 48.49; P\u2009&lt;\u20090.001), ' 'ESR (14.28 vs. 34.03; P\u2009&lt;\u20090.001), D-Dimer (485.18 vs. 1009.13; P\u2009=\u2009' '0.001), and CPK (68.93 vs. 131.48; P\u2009&lt;\u20090.001) compared to the control group. ' 'Conversely, a significant increase was observed in the mean serum levels of lymphocytes ' '(1537.06 vs. 1152.60; P\u2009&lt;\u20090.001) in the intervention group after 14 days of ' 'treatment compared to the control group. The remarkable reduction in inflammatory markers and ' 'mortality rates observed with NBS supplementation alongside standard antiviral treatment ' 'underscores its crucial role in mitigating inflammation and achieving an important milestone ' 'in the fight against COVID-19.</jats:p>', 'alternative-id': ['1690'], 'article-number': '33', 'assertion': [ { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'Received', 'name': 'received', 'order': 1, 'value': '6 January 2024'}, { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'Accepted', 'name': 'accepted', 'order': 2, 'value': '12 March 2024'}, { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'First Online', 'name': 'first_online', 'order': 3, 'value': '24 March 2024'}, {'group': {'label': 'Declarations', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 1}, { 'group': {'label': 'Ethics approval and consent to participate', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 2, 'value': 'The study protocols adhered to the principles outlined in the Helsinki ' 'Declaration, with all procedures receiving official validation from the Ethics ' 'Committee of Hamadan University of Medical Sciences (Protocol Number: ' 'IR.UMSHA.REC.1401.1043; Approval Date: 2023-03-04). Additionally, the study’s ' 'protocol has been registered in the Iranian Registry of Clinical Trials (IRCT), ' 'accessible at ExternalRef removed (IRCT Registration Number: ' 'IRCT20230116057135N2; Registration Date: 2023-04-05). The aims of the study ' 'were explained to patients. A questionnaire was prepared for each of the ' 'patients and a written informed consent was acquired from all patients.'}, { 'group': {'label': 'Consent for publication', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 3, 'value': 'Not applicable.'}, { 'group': {'label': 'Competing interests', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 4, 'value': 'All of the authors declare that there are no commercial, personal, political, ' 'or any other potential conflicting interests related to the submitted ' 'manuscript.'}], 'author': [ {'affiliation': [], 'family': 'Mosadegh', 'given': 'Mehrdad', 'sequence': 'first'}, {'affiliation': [], 'family': 'Khalkhali', 'given': 'Aref', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Erfani', 'given': 'Yousef', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Nezamdoost', 'given': 'Manije', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Hashemi', 'given': 'Seyyed Hamid', 'sequence': 'additional'}, { 'ORCID': 'http://orcid.org/0000-0003-3134-1441', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Azizi Jalilian', 'given': 'Farid', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Ansari', 'given': 'Nastaran', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Mahmoudvand', 'given': 'Shahab', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Mamani', 'given': 'Mojgan', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Abdoli', 'given': 'Elham', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Amini', 'given': 'Razieh', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Kalvandi', 'given': 'Gholamreza', 'sequence': 'additional'}], 'container-title': 'AMB Express', 'container-title-short': 'AMB Expr', 'content-domain': {'crossmark-restriction': False, 'domain': ['link.springer.com']}, 'created': {'date-parts': [[2024, 3, 24]], 'date-time': '2024-03-24T13:01:33Z', 'timestamp': 1711285293000}, 'deposited': { 'date-parts': [[2024, 3, 24]], 'date-time': '2024-03-24T13:01:43Z', 'timestamp': 1711285303000}, 'indexed': {'date-parts': [[2024, 3, 24]], 'date-time': '2024-03-24T13:44:34Z', 'timestamp': 1711287874643}, 'is-referenced-by-count': 0, 'issue': '1', 'issued': {'date-parts': [[2024, 3, 24]]}, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2024, 12]]}}, 'language': 'en', 'license': [ { 'URL': 'https://creativecommons.org/licenses/by/4.0', 'content-version': 'tdm', 'delay-in-days': 0, 'start': { 'date-parts': [[2024, 3, 24]], 'date-time': '2024-03-24T00:00:00Z', 'timestamp': 1711238400000}}, { 'URL': 'https://creativecommons.org/licenses/by/4.0', 'content-version': 'vor', 'delay-in-days': 0, 'start': { 'date-parts': [[2024, 3, 24]], 'date-time': '2024-03-24T00:00:00Z', 'timestamp': 1711238400000}}], 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1186/s13568-024-01690-8.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1186/s13568-024-01690-8/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1186/s13568-024-01690-8.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'member': '297', 'original-title': [], 'prefix': '10.1186', 'published': {'date-parts': [[2024, 3, 24]]}, 'published-online': {'date-parts': [[2024, 3, 24]]}, 'publisher': 'Springer Science and Business Media LLC', 'reference': [ { 'DOI': '10.1007/s11515-011-1123-9', 'author': 'AU Ahmed', 'doi-asserted-by': 'publisher', 'first-page': '274', 'issue': '4', 'journal-title': 'Front Biol', 'key': '1690_CR1', 'unstructured': 'Ahmed AU (2011) An overview of inflammation: mechanism and consequences. 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